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Manus Aktteva Biopharma LLP offers Letrozole, 112809-51-5, from a WHO GMP plant with the Drug Master File, Open Part DMF and DMF in CTD Format also can be made available on request
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Letrozole
Letrozole
Letrozole is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer. Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Letrozole blocks production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids. In contrast, the antiestrogenic action of tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production.
Product Reference ID: MA-MK-1014-D
Letrozole, 112809-51-5
Chemical Name: 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
Description
CAS number 112809-51-5
Synonym 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
Molecular Formula C17H11N5
Molecular Weight 285.303
Specifications USP
Packing Export worthy packing
Application For treatment of hormonally-responsive breast cancer.
Material Safety Data Sheet
Available on request
Availability For your requirements of evaluation, Pilots and Commercial procurement
Drug Master File Available
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